A landmark clinical trial examining the use of puberty-blocking drugs in gender-questioning children can begin recruiting participants from August after the High Court rejected a legal challenge seeking to halt it. On 31 July 2026, Mr Justice Chamberlain refused permission for a full judicial review, ruling that none of the campaigners’ claims had a realistic prospect of success. The decision clears the way for the NHS-funded Pathways trial, run by King’s College London, to s